The older I get, and the more life I have to look back on, the more I realize that most of the horrible things that have happened to me, have turned out to be for my good. That's not to say that every single aspect of it was fun or beneficial, but it means that what I thought was a bad thing, turned out in the long run (sometimes the very long run), to bring great things into my life.
When I couldn't afford to buy books, I went to the library instead, and ended up meeting an artist who inspired me to start painting. One of the worst times of my entire life, that lasted for over a year, resulted in my writing a novel. One time I had a neighbor that drove me crazy with noise 24 hours a day, but I was afraid to move as I felt I couldn't afford it. Finally I became so miserable, I made the move, and have loved every minute of my new home.
I think God makes us uncomfortable when He wants us to change something. He pokes at us until finally we can't take it anymore and we change direction, usually to find out that it's so much better. It isn't that God is trying to make you miserable, or has forgotten you. He's saying, "Come on. Get up. Come over here and see what's waiting for you." The other day I was having lunch with a friend and telling her about this exact idea. On the way home, I got completely lost and was so frustrated and annoyed at the wasted time and energy, and not sure how I got lost when I had been there before. I passed an art studio and decided to stop in because traffic was heavy anyway. I talked to the owner and now I'm going to have my art for sale in that gallery. Bumpy roads often lead to good things. Someone may be trying to tell you something. When things suck, search for the signs.